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1113 Haventree Rd., durham, NC 27713 • United States
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Phone (919) 302-3814 • Fax (919)806-0219 •
E-mail vweigman@expressionanalysis.com
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Victor J WeigmaN Jr.
Research
Interests:
- Translational
research in disease development
- Multi-class
prediction methods
- High-throughput
data analysis and automation
- Tool
Development
Education:
- PhD.
Biology (August 2009)
Enrolled in dual degree program of
Bioinformatics and Computational Biology
University of North Carolina at Chapel Hill
University of North Carolina at Chapel Hill
Professional
Experience:
- Analysis
of gene expression data on all major platforms (Agilent, Affymetrix,
Illumina)
- Develop
tools for analysis of gene expression and large-scale SNP data and aCGH
platforms
- Cross-species
analyses of murine and human breast cancers identifying conserved levels
of expression, copy number and sequence information
- Associations
of gene expression and copy number events to clinical features/phenotypes
- Establish
a pipeline of analyzes and visualization of Solexa and Digital Gene
Expression reads
- Developed
a analysis pipeline for biologists to do gene resequencing and visualize
mutations
- Experience
in ad-hoc platform annotation and cross-platform comparisons
Positions
Held:
- Senior
Bioinformaticist, Feb 2009 - Present
Expression Analysis, 4324 South Alston Avenue,
Durham, NC 27713
- Research
Assistant, Appointed: 2003.
University of North Carolina at Chapel Hill,
College of Arts and Sciences, Biology, Bioinformatics and Computational Biology.
Charles Perou Laboratory
- Research
Technician, Appointed: 2000.
University of North Carolina at Chapel Hill,
College of Arts and Sciences, Biology.
Jeff Dangl Laboratory
Expertise
- 8
Years experience in microarrays and experimental design
- 6
Years of statistical programming (R, Matlab)
- 4
Years of computer programming (Perl, Java, HTML, C++)
- 4
Years of molecular biology methods
- 4
Years biostatistics and linear models
- 2
Years of mathematical modeling
- 1+
Year of Genome Sequencing Analysis (Solexa, Digital Gene Expression)
- Experience
in large-group programming effort, CVS repository, etc.
Publications:
- Kim
WY, Perera S, Zhou B, Carretero J, Yeh JJ, Heathcote SA, Jackson AL,
Nikolinakos P, Ospina B, Naumov G, Brandstetter KA, Weigman VJ,
Zaghlul S, Hayes DN, Padera RF, Heymach JV, Kung A Sharpless NE, Kaelin
WG, and Wong KK, HIF2a cooperates with RAS to promote lung tumorigenesis
in mice. In Press, Journal of Clinical Investigation.
- Shabalin,
A, Weigman, VJ, Perou CM, Nobel, AB. Finding Large Average
Submatrices in High Dimensional Data. Annals of Applied Statistics. May
2009.
- Hoadley,
KA, Weigman, VJ, Fan, C., Sawyer, LR., He, X., Troester,
MA.,Sartor, CI., Rieger-House, T., Bernard, PS., Carey, LA., Perou, CM.
EGFR associated expression profiles vary with breast tumor subtype. BMC
Genomics, 8:258, July 2007.
- Herschkowitz,
JI*, Simin, K*, Weigman, VJ, et al. Identification of
conserved gene expression features between murine mammary carcinoma models
and human breast tumors. Genome Biology, 8:R76, May 2007
- Eulgem
TA, Weigman VJ, Chang HS, McDowell JM, Holub EB, Glazebrook J, Zhu
T, Dangl JL. Gene expression signatures from three genetically separable
resistance gene signaling pathways for downy mildew resistance. Plant
Physiology. 135(2): 1129-44, Jun 2004
Invited
Talks:
- Weigman,
VJ. Associations of Copy Number Variants in Breast Cancer Using Bead Chip
Technology. UNC Genetics Department Retreat. Asheville, NC, USA. September
2007
- Weigman,
VJ. Advancements in clinical prognosis based on modeling data from
high-throughput technologies. Federal University
of Ceará, Fortaleza, Brazil. August 2007.
Presented
Posters:
- Weigman
VJ, He X, Perou, C. Associations of Copy Number Variants in Breast Cancer
Using Bead Chip Technology. ISMB. Vienna, Austria, July 2007.
- Shabalin
A*, Weigman, VJ*, Perou, CM, Nobel, A. Finding Significant monochromatic
sample-variable blocks in large datasets. ISMB. Vienna, Austria, July
2007.
- Weigman
VJ, Troester M, He X, Huang CH, Perou CM. From systems to symptoms: A
combined genomics approach to expression-based breast cancer outcome
prediction. ISMB. Fortaleza, Brazil. August 2006
- Weigman
VJ, He X, Kaufman W, Perou C. Compounding Cancer Knowledge-Base:
Throwing IR Data & SNPs in the Mix. Genetics and Molecular Biology
Retreat. Wilmington, USA. September 2005
- Weigman
VJ, Leonard J, Schmitt C, Herschkowitz JI, Hu Z, He Z, Karaca G, Haaland
PD, Perou CM. Creation of a biological-relevant simulation environment
for incorporation of multi-dimensional data for prediction of patient
outcomes. ISMB. Detroit, USA. June 2005
- Weigman
VJ, Eulgem TA, Wiseman BL, Dangl JL. A comprehensive guide to analyzing
families of co-expressed genes and approaches leading to the discovery of
novel regulatory elements. Plant and Animal Genome XII, San Diego, USA.
Jan 2004.
Honors/Awards:
- J
Maryon Saunders Outstanding Kiwanian Award. September 2008.
- Highest
award of the Chapel Hill-Carrboro Kiwanis (10 in past 80 years)
- Kiwanis
International Distinguished President Award. September 2008.
- Awarded
to presidents who exceed growth levels in fundraising, membership and
service as well as participate in district and international business
·
MVP Award of Bioinformatics, Becton Dickenson Technologies,
August 2004
Membership
Information:
- American
Association for Cancer Researchers (2005-present)
- International
Society of Computational Biology-Student Council (2005-present)
- Director,
Business Relations Committee (2005-present)
- International
Society of Computational Biology (2003-present)
- Kiwanis
International, Chapel Hill-Carrboro Club (2003-present)
- President
(2007-2008)
- Board
of Directors (2004-present)
- Fundraising
Chair (2005-present)
- Triangle
(NC) Microarray User’s Group (2005-2007)
Service:
- Vienna
International Center, Student Council Symposium 3, Fundraising Coordinator
- Fortaleza
Convention Center, Student Council Symposium 2, Program Coordinator
- North
Carolina Biotechnology Center, BioMeet RTP 2006, Event Chair